Park, JH Min, HY Kim, SS Lee, JY Lee, SK Lee, YS 2024-01-21T07:42:44Z 2024-01-21T07:42:44Z 2021-09-02 2004-01 0365-6233 https://pubs.kist.re.kr/handle/201004/137988 4'-Dihydroxylated styrylquinazolines (2 a-c), 3'-hydroxylated styrylquinazolines 3', (2 h, 2 i), and 3'-acetoxy-styrylquinazolines (2 j, 2 k) exhibited good inhibitory effects of PGE(2) production by COX-2 with a range of IC50 values of 1.19 similar to 3.56 muM. The potencies were comparable or better than that of the representative stilbene resveratrol (IC50 = 3.07 muM). These results indicate that styrylquinazolines can be considered as potential resveratrol analogues in the modulation of prostaglandin production by COX-2. English WILEY-V C H VERLAG GMBH RESVERATROL DERIVATIVES POTENT Styrylquinazolines: A new class of inhibitors on prostaglandin E-2 production in lipopolysaccharide-activated macrophage cells Article 10.1002/ardp.200300791 1 ARCHIV DER PHARMAZIE, v.337, no.1, pp.20 - 24 ARCHIV DER PHARMAZIE 337 1 20 24 scie scopus 000188857200003 2-s2.0-1242269414 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article RESVERATROL DERIVATIVES POTENT styrylquinazoline prostaglandin E-2 (PGE(2)) cyclooxygenase COX resveratrol inflammation chemoprevention perkin condensation