Lee, JH Lee, KS Kang, YK Yoo, KH Shin, KJ Kim, DC Kong, JY Lee, YH Lee, SJ Kim, DJ 2024-01-21T07:43:29Z 2024-01-21T07:43:29Z 2021-09-03 2003-12-15 0960-894X https://pubs.kist.re.kr/handle/201004/137999 The synthesis and antibacterial activity of novel 1beta-methylcarbapenems 1a-f bearing oxyiminopyrrolidinylamide moiety at C-5 position of pyrrolidine are described. Most compounds exhibited comparable antibacterial activity to meropenem against a wide range of Gram-positive and Gram-negative organisms including Pseudomonas aeruginosa isolates. Of these carbapenems, 1a showed potent and broad spectrum of antibacterial activity and similar stability to DHP-I to meropenem. Against clinical isolates of 40 Gram-negative bacterial species including MDR and ESBL-producing strains, the selected carbapenem 1a possessed excellent in vitro activity except for MDR P. aeruginosa, and was comparable in potency to meropenem. (C) 2003 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ANTIBACTERIAL ACTIVITY Synthesis and biological activity of novel 1 beta-methylcarbapenems with oxyiminopyrrolidinylamide moiety Article 10.1016/j.bmcl.2003.09.039 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.24, pp.4399 - 4403 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13 24 4399 4403 scie scopus 000187010700029 2-s2.0-0344496008 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ANTIBACTERIAL ACTIVITY 1β-methylcarbapenems oxyiminopyrrolidinylamide moiety DHP-I stability MDR & ESBL-producing strains