Im, DS Cheong, CS Lee, SH Jung, YK Jeong, IH 2024-01-21T07:44:01Z 2024-01-21T07:44:01Z 2021-09-03 2003-12-01 1381-1177 https://pubs.kist.re.kr/handle/201004/138009 Chemo-enzymatic approaches for the synthesis of the family of aromatase inhibitory drug via lipase-catalyzed kinetic resolution of (+/-)-4-cyano-4-phenyl-1-hexanol (2) as appropriate precursors were described. Enzymatic transesterification of primary alcohol (+/-)-2 using Pseudomonas cepacia (Amano PS, PCL) provided the enantiopure alcohol (R)-(-)-2 with 99% ee at conversion of 86%, while that of (+/-)-2 using Pseudomonas fluorescens (Amano AK, LAK) provided the (S)-(+)-2 with 96% ee at conversion of 86%. Chemical transformation of substrate (R)-(-)-2 gave (R)-(+)-aminoglutethimide (1) in enantioselectively high yield. (C) 2003 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV BENZYLIC QUATERNARY CARBONS ASYMMETRIC CONSTRUCTION AROMATASE ANALOGS AMINOGLUTETHIMIDE 3-ETHYL-3-(4-PYRIDYL)PIPERIDINE-2,6-DIONE DERIVATIVES INHIBITION Chemo-enzymatic synthesis of (R)-(+)-aminoglutethimide by kinetic resolution of (+/-)-4-cyano-4-phenyl-1-hexanol Article 10.1016/j.molcatb.2003.06.001 1 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.26, no.3-6, pp.185 - 191 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 26 3-6 185 191 scie scopus 000187060500010 2-s2.0-0242659249 Biochemistry & Molecular Biology Chemistry, Physical Biochemistry & Molecular Biology Chemistry Article BENZYLIC QUATERNARY CARBONS ASYMMETRIC CONSTRUCTION AROMATASE ANALOGS AMINOGLUTETHIMIDE 3-ETHYL-3-(4-PYRIDYL)PIPERIDINE-2,6-DIONE DERIVATIVES INHIBITION aminoglutethimide tertiary benzylic center enzymatic resolution transesterification enantioselective