Yoo, H. Lee, J.Y. Park, J.H. Chung, B.Y. Lee, Y.S. 2024-01-21T08:02:20Z 2024-01-21T08:02:20Z 2021-09-02 2003-12 0014-827X https://pubs.kist.re.kr/handle/201004/138068 A series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50=∼40 μM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I). ？ 2003 ？ditions scientifiques et m？dicales Elsevier SAS. All rights reserved. English Elsevier Masson SAS 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid 7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid benzofuran derivative integrase inhibitor methyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate quinoline derivative unclassified drug article drug activity drug screening drug structure drug synthesis enzyme inhibition Human immunodeficiency virus 1 IC 50 nonhuman Wittig reaction Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor Article 10.1016/j.farmac.2003.08.001 1 Farmaco, v.58, no.12, pp.1243 - 1250 Farmaco 58 12 1243 1250 scopus 2-s2.0-0242468157 Article 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid 7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid benzofuran derivative integrase inhibitor methyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate methyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate quinoline derivative unclassified drug article drug activity drug screening drug structure drug synthesis enzyme inhibition Human immunodeficiency virus 1 IC 50 nonhuman Wittig reaction AIDS HIV Integrase inhibitor Styrylbenzofuran Wittig reaction