Kang, DG Lee, YS Kim, HJ Lee, YM Lee, HS 2024-01-21T08:05:18Z 2024-01-21T08:05:18Z 2021-09-03 2003-11 0378-8741 https://pubs.kist.re.kr/handle/201004/138123 The stems of Clerodendron trichotomum have been traditionally used for treatment of hypertension in far East Asia including China, Korea, and Japan. Bioassay-guided fractionation and purification of the EtOAc-soluble extract of Clerodendron trichotomum afforded acteoside (1), leucosceptoside A (2), martynoside (3), acteoside isomer (4), and isomartynoside (5). The angiotensin converting enzyme (ACE) activities were significantly inhibited by the addition of these phenylpropanoid glycosides (1-5) in a dose-dependent manner of which IC50 values were 373 +/- 9.3 mug/ml, 423 +/- 18.8 mug/ml, 524 +/- 28.1 mug/ml, 376 +/- 15.6 mug/ml, 505 +/- 26.7 mug/ml, respectively. These results suggest that the antihypertensive effect of Clerodendron trichotomum may be, at least in part, due to ACE inhibitory effect of phenylpropanoid glycosides. (C) 2003 Elsevier Ireland Ltd. All rights reserved. English ELSEVIER SCI IRELAND LTD TRADITIONAL MEDICINES BLOOD-PRESSURE ACE PLANTS HYPERTENSION VERBASCOSIDE THERAPY ESTERS Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum Article 10.1016/S0378-8741(03)00274-5 1 JOURNAL OF ETHNOPHARMACOLOGY, v.89, no.1, pp.151 - 154 JOURNAL OF ETHNOPHARMACOLOGY 89 1 151 154 scie scopus 000185993600023 2-s2.0-0141792350 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article TRADITIONAL MEDICINES BLOOD-PRESSURE ACE PLANTS HYPERTENSION VERBASCOSIDE THERAPY ESTERS Clerodendron trichotomum phenylpropanoid glycosides angiotensin converting enzyme inhibitor antihypertensive