Cho, HW Oh, CH Lee, JS Lee, SC Choi, JH Cho, JH 2024-01-21T08:05:34Z 2024-01-21T08:05:34Z 2021-09-03 2003-11 0365-6233 https://pubs.kist.re.kr/handle/201004/138128 The synthesis of a new series of 2-alkyl-4-pyrrolidinylthio-b-methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds (14b, 14c) containing 3-methyl- and 3,5-dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity. English WILEY-V C H VERLAG GMBH 1-BETA-METHYLCARBAPENEM THIENAMYCIN ANTIBIOTICS FR21818 Synthesis and antibacterial activities of 4-pyrrolidinylthio carbapenems: Containing heteroaromatics as a side chain Article 10.1002/ardp.200300728 1 ARCHIV DER PHARMAZIE, v.336, no.11, pp.495 - 503 ARCHIV DER PHARMAZIE 336 11 495 503 scie scopus 000187229900001 2-s2.0-0348108047 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article 1-BETA-METHYLCARBAPENEM THIENAMYCIN ANTIBIOTICS FR21818 carbapenems antibacterials DHP-I stability