Kim, MJ Kim, HO Kim, HD Kim, JH Jeong, LS Chun, MW 2024-01-21T08:06:13Z 2024-01-21T08:06:13Z 2021-09-03 2003-10-20 0960-894X https://pubs.kist.re.kr/handle/201004/138140 The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities. (C) 2003 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ANALOGS Synthesis and biological evaluation of thymine nucleosides fused with 3 ',4 '-tetrahydrofuran ring Article 10.1016/S0960-894X(03)00730-3 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.20, pp.3499 - 3501 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13 20 3499 3501 scie scopus 000185590300023 2-s2.0-0141851413 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ANALOGS thymine nucleosides tetrahydrofuran