김수형 안광덕 한동근 이영무 2024-01-21T08:13:30Z 2024-01-21T08:13:30Z 2021-09-06 2003-09 1226-4601 https://pubs.kist.re.kr/handle/201004/138275 Biodegradable polylactic acid (PLA) is relatively biocompatible and appropriately biodegradable, but it lacks the ability to interact biospecifically with cells. In order to make ligand-immobilizable functional PLA scaffolds for tissue engineering, two kinds of biodegradable crosslinked polymer scaffold networks were prepared with glycerol (G)-lactide (L) triacrylate (GL-Ac) and acrylic acid (AA) or poly(acrylic acid) (PAA) by UV photopolymerization. The bulk and surface characteristics and cell adhesion behavior of the obtained GL-AA network and GL-PAA semi-IPN network films were evaluated. The GL-AA and GL-PAA networks showed good bulk properties and AA-enriched and hydrophilic surfaces. In addition, the GL-AA network displayed more adhesion and spreading of fibroblast than GL one. These new hydrophilic GL-AA/PAA polymer networks are expected to be useful as ligand-immobilizable scaffolds for specific cell adhesion in the regeneration of artificial tissues and organs. 한국생체재료학회 리간드 고정이 가능한 아크릴산을 함유한 조직공학용 생분해성 고분자 지지체 Network 의 제조 및 특성 Preparation and Characteristics of Biodegradable Polymer Scaffold networks Containing Ligand-immobilizable Acrylic Acid for Tisssue Engineering Article 2 생체재료학회지, v.7, no.3, pp.175 - 181 생체재료학회지 7 3 175 181 ART000993691 Tissue engineering Biodegradable scaffolds GL network Chemical modification Acrylic acid Hydrophilization Cell adhesion