Oh, CH Lee, SC Cho, JH 2024-01-21T08:14:28Z 2024-01-21T08:14:28Z 2021-09-03 2003-09 0223-5234 https://pubs.kist.re.kr/handle/201004/138293 The synthesis of a new series of 1beta-methylcarbapenems having the substituted aminoethylcarbamoylpyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, the compound 11g having piperazinyl urea moiety showed the most potent antibacterial activity and Ilk exhibited excellent anti-MRSA. (C) 2003 editions scientifiques et medicales Elsevier SAS. All rights reserved. English EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER ANTIBACTERIAL ACTIVITY CARBAPENEM SM-7338 Synthesis and biological activity of 1 beta-methyl-2-[5-(2-N-substituted aminoethylcarbamoyl)pyrrolidin-3-ylthio]carbapenem derivatives Article 10.1016/S0223-5234(03)00143-0 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.38, no.9, pp.841 - 850 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 38 9 841 850 scie scopus 000186246500006 2-s2.0-0141953262 Chemistry, Medicinal Pharmacology & Pharmacy Article ANTIBACTERIAL ACTIVITY CARBAPENEM SM-7338 1 beta-methylcarbapenem antibacterial activity substituent effect