Park, JH Cho, YW Cho, YH Choi, JM Shin, HJ Bae, YH Chung, H Jeong, SY Kwon, IC 2024-01-21T08:15:03Z 2024-01-21T08:15:03Z 2021-09-01 2003-09 0920-5063 https://pubs.kist.re.kr/handle/201004/138304 Norfloxacin-releasing urethral catheters were prepared for the purpose of preventing urinary tract infections during long-term catheterization. The outer and inner surfaces of the catheters were coated with poly(ethylene-co-vinyl acetate) (EVA) and an amphiphilic multiblock co-polymer (PEO2kPDMS), composed of poly(ethylene oxide) and poly(dimethyl siloxane). Norfloxacin, a fluoroquinolone synthetic antibiotic, was impregnated into a coating layer. The in vitro drug release behavior was monitored for 30 days, the surface topography was investigated using scanning electron microscopy (SEM) and the antibacterial activity against different bacteria implicated in urinary tract infection was evaluated by the in vitro inhibition zone test. All the coated catheters showed continuous delivery of norfloxacin for up to 30 days owing to hydrophobic natures of norfloxacin and EVA. PEO2kPDMS incorporated in a coating layer produced a smooth and uniform surface. The coated catheters created considerable inhibition zones for 10 days against Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris, indicating the continuous release of norfloxacin. Overall, it was evident that the catheters coated with EVA/PEO2kPDMS blends containing norfloxacin have a promising potential for the clinical use in patients undergoing long-term catheterization. English VSP BV URINARY-TRACT-INFECTION COPOLYMER/SEGMENTED POLYURETHANE BLENDS BACTERIURIA ENCRUSTATION BIOCOMPATIBILITY BIOMATERIALS BACTEREMIA MORTALITY BEHAVIOR EFFICACY Norfloxacin-releasing urethral catheter for long-term catheterization Article 10.1163/156856203322381438 1 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.14, no.9, pp.951 - 962 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 14 9 951 962 scie scopus 000187210400006 2-s2.0-0242300786 Engineering, Biomedical Materials Science, Biomaterials Polymer Science Engineering Materials Science Polymer Science Article URINARY-TRACT-INFECTION COPOLYMER/SEGMENTED POLYURETHANE BLENDS BACTERIURIA ENCRUSTATION BIOCOMPATIBILITY BIOMATERIALS BACTEREMIA MORTALITY BEHAVIOR EFFICACY urethral catheter long-term catheterization EVA multiblock co-polymer norfloxacin controlled release inhibition zone