Song, SC Lee, SB Lee, BH Ha, HW Lee, KT Sohn, YS 2024-01-21T08:35:01Z 2024-01-21T08:35:01Z 2021-09-03 2003-07-31 0168-3659 https://pubs.kist.re.kr/handle/201004/138393 Thermosensitive cyclotriphosphazenes bearing alkoxy poly(ethylene glycol) and amino acid esters as side groups could be functionalized to chelate the antitumor (diamine)platinum(II) moiety through the dicarboxylate group of the amino acid substituent on the cyclic phosphazene ring. Surprisingly, like the precursor cyclotriphosphazenes, these (diamine)platinum(II)-cyclotriphosphazene conjugates were also found to exhibit variable lower critical solution temperatures (LCST) in the wide range of 12 to 92 T. Furthermore, the present conjugates have shown outstanding in vitro and in vivo antitumor activities due to controlled release of the antitumor (diamine)platinum(II) moiety with hydrolytic degradation of the phosphazene ring. A few of these conjugates have shown LCSTs below body temperature, and it has been shown from a model animal experiment that the conjugates with a LCST below body temperature may be applied to local drug delivery by direct intratumoral injection. (C) 2003 Elsevier B.V. All rights reserved. English ELSEVIER AMINO-ACID ESTERS DRUG-DELIVERY COMPLEXES POLYMERS GLYCOL) Synthesis and antitumor activity of novel thermosensitive platinum(II)-cyclotriphosphazene conjugates Article 10.1016/S0168-3659(03)00199-8 1 JOURNAL OF CONTROLLED RELEASE, v.90, no.3, pp.303 - 311 JOURNAL OF CONTROLLED RELEASE 90 3 303 311 scie scopus 000184636100004 2-s2.0-0037768711 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article AMINO-ACID ESTERS DRUG-DELIVERY COMPLEXES POLYMERS GLYCOL) anticancer drug thermosensitive platinum conjugates cyclotriphosphazene lower critical solution temperature