Lee, SB Sohn, YS Song, SC 2024-01-21T08:35:24Z 2024-01-21T08:35:24Z 2021-09-03 2003-07-20 0253-2964 https://pubs.kist.re.kr/handle/201004/138400 The lower critical solution temperature (LCST) of thermosensitive poly(organophosphazenes) with methoxypoly(ethylene glycol) (MPEG) and amino acid esters as side groups was studied as a function of saccharide concentration in aqueous Solutions of mono-, di-, and polysaccharides. Most of the saccharides decreased the LCST of the polymers, and the LCST decrease was more prominently observed by saccharides containing a galactose ring, such as D-galactose, D-galactosamine and D-lactose, and also the polysacccharide, 1-6-linked D-dextran effectively decreased the LCST of the polymers. Such an effect was discussed in terms of intramolecular hydrogen bonding of saccharides in polymer aqueous solution. The saccharide effect was found to be almost independent on the kinds of the amino acid esters and MPEG length of the polymers. Such a result implies that the polymer-saccharide interaction in aqueous solution is clearly influenced by the structure of sacchardes rather than by that of the polymers. The acid saccharides such as D-glucuronic and D-lactobionic acid increased the LCST, which seems to be due to their pH effect. English KOREAN CHEMICAL SOC HYDROLYSIS-SENSITIVE POLY<(ORGANO)PHOSPHAZENES> BIODEGRADABLE THERMOSENSITIVE POLYMERS PHASE-TRANSITION POLY(N-ISOPROPYLACRYLAMIDE) GEL AQUEOUS-SOLUTIONS PH HYDROGELS COPOLYMER SYSTEM Saccharide effect on the lower critical solution temperature of poly(organophosphazenes) with methoxy-poly(ethylene glycol) and amino acid esters as side groups Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.24, no.7, pp.901 - 905 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 24 7 901 905 scie scopus kci ART000912873 000185709700009 2-s2.0-0344444663 Chemistry, Multidisciplinary Chemistry Article HYDROLYSIS-SENSITIVE POLY<(ORGANO)PHOSPHAZENES> BIODEGRADABLE THERMOSENSITIVE POLYMERS PHASE-TRANSITION POLY(N-ISOPROPYLACRYLAMIDE) GEL AQUEOUS-SOLUTIONS PH HYDROGELS COPOLYMER SYSTEM polyphosphazene LCST saccharide effect intramolecular hydrogen bonding