Oh, CH Lee, SC Cho, JH 2024-01-21T08:35:49Z 2024-01-21T08:35:49Z 2022-01-11 2003-07 0223-5234 https://pubs.kist.re.kr/handle/201004/138407 The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved. English ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER CARBAPENEM Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio]carbapenem derivatives Article 10.1016/S0223-5234(03)00116-8 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.38, no.7-8, pp.751 - 758 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 38 7-8 751 758 scie scopus 000185622500011 2-s2.0-0042657886 Chemistry, Medicinal Pharmacology & Pharmacy Article CARBAPENEM 1 beta-methylcarbapenem beta-lactam antibiotics