Yoo, KH Choi, HS Kim, DC Shin, KJ Kim, DJ Song, YS Jin, C 2024-01-21T08:37:56Z 2024-01-21T08:37:56Z 2021-09-03 2003-07 0365-6233 https://pubs.kist.re.kr/handle/201004/138446 Heteroarylpiperazine and heteroarylbipiperidine derivatives, bearing a 4-piperidine ring instead of an alkylamino side chain to give the semi-rigidity, were prepared and evaluated for their abilities to displace [H-3] 8-OH-DPAT binding to the rat hippocampal synaptic membranes. These compounds showed low to moderate affinities for 5HT(1A) receptor, with Ki values ranging from 6912 nM to 232 nM. Of these compounds, 8 b and 15 e exhibited the best affinities for 5-HT1A receptor with Ki values of 232 nM and 338 nM, respectively. English WILEY-V C H VERLAG GMBH ANXIETY DEPRESSION BINDING SITES Synthesis of heteroarylpiperazines and heteroarylbipiperidines with a restricted side chain and their affinities for 5-HT1A receptor Article 10.1002/ardp.200300721 1 ARCHIV DER PHARMAZIE, v.336, no.4-5, pp.208 - 215 ARCHIV DER PHARMAZIE 336 4-5 208 215 scie scopus 000184659800002 2-s2.0-0042235082 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article ANXIETY DEPRESSION BINDING SITES heteroarylpiperazines heteroarylbipiperidines restricted side chain 5-HT1A receptor affinities