Jeon, D Yang, YM Jeong, MJ Philipson, KD Rhim, H Shin, HS 2024-01-21T08:42:34Z 2024-01-21T08:42:34Z 2021-09-03 2003-06 0896-6273 https://pubs.kist.re.kr/handle/201004/138530 The plasma membrane Na+/Ca2+ exchanger (NCX) plays a role in regulation of intracellular Ca2+ concentration via the forward mode (Ca2+ efflux) or the reverse mode (Ca2+ influx). To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain. Mutant hippocampal neurons exhibited a significantly delayed clearance of elevated Ca2+ following depolarization. The frequency threshold for LTP and LTD in the hippocampal CA1 region was shifted to a lowered frequency in the mutant mice, thereby favoring LTP. Behaviorally, the mutant mice exhibited enhanced performance in several hippocampus-dependent learning and memory tasks. These results demonstrate that NCX2 can be a temporal regulator of Ca2+ homeostasis and as such is essential for the control of synaptic plasticity and cognition. English CELL PRESS Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2 Article 10.1016/S0896-6273(03)00334-9 1 NEURON, v.38, no.6, pp.965 - 976 NEURON 38 6 965 976 N scie scopus 000183691400015 2-s2.0-0037523361 Neurosciences Neurosciences & Neurology Article LONG-TERM POTENTIATION SODIUM-CALCIUM EXCHANGE CALMODULIN KINASE-II CRAYFISH NEUROMUSCULAR-JUNCTION DEPENDENT SYNAPTIC PLASTICITY RAT-BRAIN NA+-CA2+ EXCHANGER INTRACELLULAR CALCIUM NEURONAL PREPARATIONS MOLECULAR-CLONING