Deng, WP Nam, G Fan, JF Kirk, KL 2024-01-21T09:04:59Z 2024-01-21T09:04:59Z 2021-09-01 2003-04-04 0022-3263 https://pubs.kist.re.kr/handle/201004/138652 Tryptamines disubstituted at the beta-position with fluorine have been synthesized as part of our research program to study the effects of fluorine substitution on the biological activities of neuroactive amines. Treatment of N-Boc-3-azidoacetyl indoles, prepared from readily available 2-chloracetylindoles, with dimethoxyethylamino sulfurtrifluoride produced the corresponding 3-(2-azido-1,1-difluoroethyl)indoles. Reduction of the azide to amine with hydrogen over Pd-C and careful removal of the N-Boc protecting group produced beta,beta-difluorotryptamines. English AMER CHEMICAL SOC IMIDAZOLE Syntheses of beta,beta-difluorotryptamines Article 10.1021/jo020731c 1 JOURNAL OF ORGANIC CHEMISTRY, v.68, no.7, pp.2798 - 2802 JOURNAL OF ORGANIC CHEMISTRY 68 7 2798 2802 scie scopus 000181953700034 Chemistry, Organic Chemistry Article IMIDAZOLE Fluorinated tryptamine fluorinated serotonine Fluorination of side chain of amine