Kim, BH Chung, EY Ryu, JC Jung, SH Min, KR Kim, Y 2024-01-21T09:08:36Z 2024-01-21T09:08:36Z 2021-09-03 2003-04 0253-6269 https://pubs.kist.re.kr/handle/201004/138719 Soy, high dietary intake for the oriental population, is a main source of isoflavonoids. Sophoricoside (SOP) an isoflavone glycoside was isolated from immature fruits of Sophora japonica (Leguminosae family) and its inhibitory effect on chemical mediators involved in inflammatory response was investigated in this study. SOP inhibited the interleukin (IL)-6 bioactivity with an IC50 value of 6.1 muM whereas it had no effects on IL-1beta and TNF-alpha bioactivities. SOP was identified as a selective inhibitor of cyclooxygenase (COX)-2 activity with an IC50 value of 4.4 muM, but did not show inhibitory effect on the synthesis of COX-2. However, SOP had no effect on the production of reactive oxygen species including superoxide anions and nitric oxide. These results revealed that in vitro anti-inflammatory action of SOP is significantly different from that of. genistein known as a phytoestrogen of soy products. This experimental study has documented an importance of dietary soy isoflavonoids as multifunctional agents beneficial to human health, and will help to clarify protective mechanisms of SOP against inflammatory conditions. English PHARMACEUTICAL SOC KOREA ANALOGS SYNTHASE CELLS Anti-inflammatory mode of isoflavone glycoside sophoricoside by inhibition of interleukin-6 and cyclooxygenase-2 in inflammatory response Article 10.1007/BF02976960 1 ARCHIVES OF PHARMACAL RESEARCH, v.26, no.4, pp.306 - 311 ARCHIVES OF PHARMACAL RESEARCH 26 4 306 311 scie scopus kci ART001186094 000182563700010 2-s2.0-0642312370 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article ANALOGS SYNTHASE CELLS Sophora japonica sophoricoside anti-inflammation interleukin-6 cyclooxygenase