Lee, JY Bang, SH Lee, SJ Song, YS Jin, CB Park, H Lee, YS 2024-01-21T09:41:24Z 2024-01-21T09:41:24Z 2021-09-01 2002-11 0253-2964 https://pubs.kist.re.kr/handle/201004/139044 Tetracyclic pyrido[2,3-b]azepine derivatives 4a-d and 4f as analogues of mirtazapine were synthesized via N-acyliminium ion cyclization by using aromatic rings such as benzene and thiophene ring as pi-nucleophile., and evaluated for the binding affinity for alpha(2)-adrenoceptor. Among tested compounds, 2.3,9,13b-tetrahydro-1H-benzo[f]pyrrolo[2,1,-a]pyrido[2,3-c]azepine (4a) was the most potent (K-i = 0.26 muM) but showed about 3-fold less binding affinity than mirtazapine (K-i = 0.08 muM) for alpha(2)-adrenoceptor. English KOREAN CHEMICAL SOC Synthesis of tetracyclic pyrido[2,3-b]azepine derivatives as analogues of mirtazapine via N-acyliminium ion cyclization Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.23, no.11, pp.1623 - 1628 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 23 11 1623 1628 N scie scopus kci ART001190442 000180236900023 2-s2.0-0037146475 Chemistry, Multidisciplinary Chemistry Article ALPHA(2)-ADRENOCEPTOR ANTAGONIST MIANSERIN TRANSMISSION REDUCTION RECEPTORS SYSTEM pyrido[2,3-b]azepine N-acyliminium ion cyclization alpha(2)-adrenoceptor mirtazapine