Kim, YH Cheong, CS Lee, SH Jun, SJ Kim, KS Cho, HS 2024-01-21T09:41:47Z 2024-01-21T09:41:47Z 2021-09-01 2002-11-13 0957-4166 https://pubs.kist.re.kr/handle/201004/139051 Dioxolane alcohol (+/-)-1 and the corresponding acid (+/-)-2 were kinetically resolved into their respective enantiomers by lipase-catalyzed hydrolysis and esterification reactions. Various alcohols were tested to resolve the acid (+/-)-2, and the desired (2R,4R)-isomer of the acid was obtained with >96% ee as the best result. Halogenated solvents such as methylene chloride and 1,2-dichloroethane were found to raise the reactivity and selectivity of the system. After recrystallization, the purity of the desired (2R,4R)-acid could be increased to over 98% ee. (C) 2002 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD KETOCONAZOLE ESTER Lipase-catalyzed resolution of 1,3-dioxolane derivatives: synthesis of a homochiral intermediate for antifungal agents Article 10.1016/S0957-4166(02)00662-6 1 TETRAHEDRON-ASYMMETRY, v.13, no.22, pp.2501 - 2508 TETRAHEDRON-ASYMMETRY 13 22 2501 2508 scie scopus 000179567000015 2-s2.0-0037073345 Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Chemistry Article KETOCONAZOLE ESTER lipase resolution dioxolane antifungal agent