Kim, HJ Yu, YG Park, H Lee, YS 2024-01-21T09:45:25Z 2024-01-21T09:45:25Z 2021-09-01 2002-11 0032-0943 https://pubs.kist.re.kr/handle/201004/139116 By means of HIV gp41 binding affinity directed chromatographic fractionation, three phenylethanoid glycosides; calceolarioside A (1), calceolarioside B (2) and acteoside (3), along with four hydroxycoumarins; esculin (4), fraxin (5), fraxetin (6) and esculetin (7), and one lignan, (-)-olivil (8) were isolated from the n-butyl alcohol fraction of Fraxinus sieboldiana var. angustata. Among the isolated compounds, calceolarioside B (2) and esculetin (7) showed moderate binding affinity on HIV gp41 with IC50 values of 0.1 mg/ml and 0.5 mg/ml, respectively. Calceolarioside A (1), calceolarioside B (2), acteoside (3), and (-)-olivil (8) were isolated for the first time from this plant. English GEORG THIEME VERLAG KG HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata Article 10.1055/s-2002-35665 1 PLANTA MEDICA, v.68, no.11, pp.1034 - 1036 PLANTA MEDICA 68 11 1034 1036 N scie scopus 000179766100017 2-s2.0-0036863669 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article INHIBITION GLUCOSIDES GLYCOSIDE TYPE-1 HIV AIDS gp41 fraxinus sieboldiana chromone lignan