Watanabe, J Ooya, T Nitta, KH Park, KD Kim, YH Yui, N 2024-01-21T10:04:07Z 2024-01-21T10:04:07Z 2021-09-01 2002-10 0142-9612 https://pubs.kist.re.kr/handle/201004/139184 Fibroblast culture was performed to evaluate cell adhesion and proliferation on poly(ethylene glycol) (PEG) hydrogels crosslinked by a hydrolyzable polyrotaxane. The polyrotaxane consisting of alpha-cyclodextrins (alpha-CDs) and PEG terminated by benzyloxycarbonyl (Z)-L-phenylalanine (L-Phe) via ester linkage was used as a multi-functional crosslinker in the PEG hydrogels. From the results of contact angle and small angle light scattering measurements, it was suggested that the surface and bulk structure of the PEG hydrogels were heterogeneous. Fibroblast adhesion and proliferation on the hydrogels was observed. The number of fibroblast adhesion on the hydrogels crosslinked by the polyrotaxane was proportional to contact angle values and correlation length, and was significantly higher than those crosslinked by alpha-CDs in spite of similar contact angle and correlation length. These findings suggest that the cells recognize the surface heterogeneity due to the polyrotaxane structure, and the number of cell adhesion and proliferation is controllable by the polyrotaxane content in feed. (C) 2002 Elsevier Science Ltd. All rights reserved. English ELSEVIER SCI LTD BIODEGRADABLE POLYROTAXANES SURFACES PREVENTION NETWORKS Fibroblast adhesion and proliferation on poly(ethylene glycol) hydrogels crosslinked by hydrolyzable polyrotaxane Article 10.1016/S0142-9612(02)00122-9 1 BIOMATERIALS, v.23, no.20, pp.4041 - 4048 BIOMATERIALS 23 20 4041 4048 scie scopus 000177233600001 2-s2.0-0035988655 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article BIODEGRADABLE POLYROTAXANES SURFACES PREVENTION NETWORKS hydrolyzable polyrotaxane hydrogel fibroblast adhesion proliferation