Roh, EJ Kim, D Lee, CO Choi, SU Song, CE 2024-01-21T10:04:11Z 2024-01-21T10:04:11Z 2021-09-01 2002-10 0968-0896 https://pubs.kist.re.kr/handle/201004/139185 A series of 3'-N-acyl-paclitaxel analogues la-v were synthesized and their cytotoxicities in vitro against several human tumor cell lines examined. It has been shown that distinct correlation between activity and N-acyl-substituent. The appropriate size of N-acyl group was indispensable for cytotoxicity, and moreover, the presence of beta-substituted conjugated double and triple bond to N-carbonyl generally resulted in increase of cytotoxicities. (C) 2002 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ANTITUMOR AGENTS TAXOL Structure-activity relationship study at the 3 '-N-position of paclitaxel: Synthesis and biological evaluation of 3 '-N-acyl-paclitaxel analogues Article 10.1016/S0968-0896(02)00218-3 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.10, no.10, pp.3145 - 3151 BIOORGANIC & MEDICINAL CHEMISTRY 10 10 3145 3151 scie scopus 000177834100006 2-s2.0-0036336629 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article ANTITUMOR AGENTS TAXOL SAR