Cha, MY Choi, BC Kang, KH Pae, AN Choi, KI Cho, YS Koh, HY Lee, HY Jung, D Kong, JY 2024-01-21T10:37:42Z 2024-01-21T10:37:42Z 2021-09-01 2002-05-20 0960-894X https://pubs.kist.re.kr/handle/201004/139519 A piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D-2, D-3, and D-4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D-3 and D-4 receptors over the D-2 receptor. Compounds 6s and 6t showed K-i values of 2.6 nM and 3.9 nM for the D-3 receptor with 46- and 50-fold selectivity over the D-3 receptor, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD MOLECULAR-CLONING HIGH-AFFINITY D-3 RECEPTOR ANTAGONIST GENE HALOPERIDOL EFFICACY AGONIST CYCLASE POTENT Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands Article 10.1016/S0960-894X(02)00179-8 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.12, no.10, pp.1327 - 1330 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 10 1327 1330 scie scopus 000175648800001 2-s2.0-18344391187 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article MOLECULAR-CLONING HIGH-AFFINITY D-3 RECEPTOR ANTAGONIST GENE HALOPERIDOL EFFICACY AGONIST CYCLASE POTENT piperazinyalkylisoxazole