Song, R Kim, YS Sohn, YS 2024-01-21T10:42:14Z 2024-01-21T10:42:14Z 2021-09-05 2002-04-10 0162-0134 https://pubs.kist.re.kr/handle/201004/139600 We have designed and synthesized a series of novel water soluble porphyrins and their platinum(11) conjugates, cis-[(Por)Pt(dmso)X], where Por=5-(4-pyridyl)-10,15,20-tris(4-sulfonatophenyl)porphyrin) (PyTPPS) or 5-[4-(3-aminopropyl)pyridiniumyl]-10,15,20-tris(4-sulphonatophenyl)porphyrin (PyTPPS-NPn), X = 2Cl, 1,1-cyclobutanedicarboxylic acid, oxalate, or malonate. Their biodistribution in tumor bearing mouse was examined along with their antitumor activity against murine leukemia L1210 cell line. The representative complex I exhibited a significant accumulation in tumor tissue with a tumor/muscle ratio of 7 after 24 It post injection. The antitumor activity of the title compounds was marginal (TIC: 95-117%), but it was found that platinum(II) coordination to the porphyrin periphery did not affect the tumor accumulating properties of the porphyrin permitting further derivatization for efficient delivery of the Pull) antitumor agent. (C) 2001 Elsevier Science Inc. All rights reserved. English ELSEVIER SCIENCE INC PLATINUM(II) COMPLEXES PHOTODYNAMIC THERAPY ANTITUMOR-ACTIVITY PHOTOSENSITIZERS PHTHALOCYANINE LOCALIZATION LIGANDS AGENTS CELL Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates Article 10.1016/S0162-0134(01)00413-5 1 JOURNAL OF INORGANIC BIOCHEMISTRY, v.89, no.1-2, pp.83 - 88 JOURNAL OF INORGANIC BIOCHEMISTRY 89 1-2 83 88 scie scopus 000175725700012 2-s2.0-0037051780 Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear Biochemistry & Molecular Biology Chemistry Article PLATINUM(II) COMPLEXES PHOTODYNAMIC THERAPY ANTITUMOR-ACTIVITY PHOTOSENSITIZERS PHTHALOCYANINE LOCALIZATION LIGANDS AGENTS CELL platinum porphyrin antitumor agent targeting