Dal Park, H Lee, WK Ooya, T Park, KD Kim, YH Yui, N 2024-01-21T10:45:41Z 2024-01-21T10:45:41Z 2021-09-05 2002-04 0021-9304 https://pubs.kist.re.kr/handle/201004/139663 Polyrotaxanes, in which alpha-cyclodextrins (alpha-CDs) are threaded onto poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol) triblock copolymers (Pluronic) capped with benzyloxycarbonyl(Z)-L-phenylalanine (Z-L-Phe), wore prepared and sulfopropyl groups were introduced to hydroxyl groups of alpha-CDs in the polyrotaxanes. The supramolecular structure and the chemical composition of the polyrotaxanes after the sulfonation were confirmed by H-1-NMR, C-13-NMR, and elemental analysis. Anticoagulant activity of the polyrotaxanes and sulfonated polyrotaxanes was measured by activated partial thromboplastin time (APTT). It was found that the polyrotaxanes and the sulfonated polyrotaxanes showed greater anticoagulant activity than Pluronic itself, suggesting that both the supramolecular structure of the polyrotaxanes and the sulfonated groups contribute to the inhibition of intrinsic coagulation factors. Finally, our designed polyrotaxanes are suggested to be a promising candidate when fabricating blood-compatible medical devices by blending with or coating on clinically used polymers. (C) 2002 John, Wiley Sons, Inc. English JOHN WILEY & SONS INC PROTEIN ADSORPTION BIODEGRADABLE POLYROTAXANES DRUG-DELIVERY PEO CYCLODEXTRINS COPOLYMERS SURFACES PREVENTION COMPOSITES ADHESION Anticoagulant activity of sulfortated polyrotaxanes as blood-compatible materials Article 1 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, v.60, no.1, pp.186 - 190 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 60 1 186 190 scie scopus 000173687700022 2-s2.0-0036162244 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article PROTEIN ADSORPTION BIODEGRADABLE POLYROTAXANES DRUG-DELIVERY PEO CYCLODEXTRINS COPOLYMERS SURFACES PREVENTION COMPOSITES ADHESION polyrotaxane sulfunated polyrotaxane anticoagulant activity amphiphilic surface-modifying polymer blood-compatible materials