Lee, BS Chu, SY Lee, BS Chi, DY SONG, YUN SEON Jin, CB 2024-01-21T11:05:28Z 2024-01-21T11:05:28Z 2021-09-05 2002-03 0960-894X https://pubs.kist.re.kr/handle/201004/139754 Eleven 4-substituted derivatives of 6-nitroquipazine were synthesized and evaluated for their abilities to displace [H-3]citalopram binding to the rat cortical synaptic membranes. Among them, 4-chloro-6-nitroquipazine was shown to possess the highest binding affinity (K-i - 0.03 nM) which was approximately 6 times higher than that of 6-nitroquipazine (K-i = 0.17 nM) itself. In this paper, we describe the syntheses of 4-substituted 6-nitroquipazine derivatives, the results of corresponding biological evaluation and the SAR study. (C) 2002 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines Article 10.1016/S0960-894X(02)00028-8 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.12, no.5, pp.811 - 815 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 5 811 815 N scie scopus 000174449500021 2-s2.0-0037060912 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article 5-HYDROXYTRYPTAMINE UPTAKE SITES H-3 6-NITROQUIPAZINE RAT-BRAIN INHIBITORS EXPRESSION POTENCY CLONING LIGAND 6-nitroquipazine analogues