Nam, G Kim, SH Kim, JH Shin, JH Jang, ES 2024-01-21T11:13:38Z 2024-01-21T11:13:38Z 2021-09-04 2002-01 1083-6160 https://pubs.kist.re.kr/handle/201004/139899 With a new reagent developed for the selective monoethylation at the 1-amino group of sisomicin (1), a new process suitable for the mass production of netilmicin under conditions less sensitive to air and moisture has also been developed. Three of the amino groups, at the C-3, C-2'. and C-6' positions of the four amino groups of sisomicin, were selectively protected by using Zn(OAc)(2) and acetic anhydride in methanol. Development efforts focused on optimising the conditions for ethylation to give an improved product (96% yield) according to the new and concise synthetic route. English AMER CHEMICAL SOC An efficient and selective 1-N-monoethylation of sisomicin: Process development of netilmicin Article 10.1021/op000076f 1 ORGANIC PROCESS RESEARCH & DEVELOPMENT, v.6, no.1, pp.78 - 81 ORGANIC PROCESS RESEARCH & DEVELOPMENT 6 1 78 81 scie scopus 000173533400015 2-s2.0-0036343121 Chemistry, Applied Chemistry, Organic Chemistry Article monoethylation