Song, KH Lee, CH Lim, JS Lee, YW 2024-01-21T11:13:41Z 2024-01-21T11:13:41Z 2021-09-04 2002-01 0256-1115 https://pubs.kist.re.kr/handle/201004/139900 Submicron particles of L-polylactic acid (L-PLA) without residual solvent were prepared by a continuous supercritical antisolvent (SAS) recrystallization process. Methylene chloride (CH2Cl2) was used as a carrier solvent of L-PLA. Experiments were performed with changing process parameters such as pressure and temperature at constant concentration. Also, L-PLA initial concentrations in methylene chloride were varied from 0.3 to 4 wt%. The flow rates of CO2, and solution, which were introduced into the precipitator, and nozzle diameter were kept unchanged in all of the experiments. It was found that the SAS process gives fine tuning of particle size and particle size distribution (PSD) by simple manipulations of the process parameters. In all cases of SAS recrystallization experiments, the formed spherical fine particles with a smooth surface were non-agglomerated and free flowing. Mean particle size of the L-PLA microparticles formed was varied from 0.1 to 1 mum by means of adjusting the system pressure and/or temperature. English KOREAN INST CHEM ENGINEERS FLUID ANTISOLVENT CARBON-DIOXIDE RELEASE DRUGS Preparation of L-PLA submicron particles by a continuous supercritical antisolvent precipitation process Article 10.1007/BF02706887 1 KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.19, no.1, pp.139 - 145 KOREAN JOURNAL OF CHEMICAL ENGINEERING 19 1 139 145 scie scopus kci ART001195819 000173666000021 2-s2.0-0036104317 Chemistry, Multidisciplinary Engineering, Chemical Chemistry Engineering Article FLUID ANTISOLVENT CARBON-DIOXIDE RELEASE DRUGS biodegradable polymer poly(L-lactic acid) supercritical antisolvent recrystallization atomization