Chung, KH Lim, CH Lee, DR Jin, CB Chi, DY 2024-01-21T11:14:49Z 2024-01-21T11:14:49Z 2021-09-05 2001-12-03 0960-894X https://pubs.kist.re.kr/handle/201004/139919 Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3 beta -aryl-2 beta-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [H-3]2 beta -carbomethoxy-3 beta-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes. (C) 2001 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD POSITRON EMISSION TOMOGRAPHY CENTRAL NERVOUS-SYSTEM PARKINSONS-DISEASE IMAGING AGENTS COCAINE ESTERS <TC-99M>TRODAT-1 INHIBITION CHEMISTRY PROVIDES Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies Article 10.1016/S0960-894X(01)00625-4 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.11, no.23, pp.3077 - 3080 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 11 23 3077 3080 scie scopus 000172267600020 2-s2.0-0035803053 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article POSITRON EMISSION TOMOGRAPHY CENTRAL NERVOUS-SYSTEM PARKINSONS-DISEASE IMAGING AGENTS COCAINE ESTERS <TC-99M>TRODAT-1 INHIBITION CHEMISTRY PROVIDES tropane analogues