Huh, KM Ooya, T Lee, WK Sasaki, S Kwon, Ick Chan Jeong, Seo Young Yui, N 2024-01-21T11:15:05Z 2024-01-21T11:15:05Z 2022-04-05 2001-12 0024-9297 https://pubs.kist.re.kr/handle/201004/139924 Supramolecular-structured hydrogels were prepared on basis of the inclusion complexation between poly(ethylene glycol) grafted dextrans and alpha-cyclodextrins (alpha -CDs) in aqueous media. The inclusion complexes from the PEG grafted dextrans showed a unique gel-sol phase transition which cannot be obtained from usual polymer inclusion complexes that form crystalline precipitates. The gel-sol transition was based on the supramolecular assembly and dissociation, and the transition was reversible with hysteresis. The transition temperature was controllable by variation in the polymer concentration and the PEG content in the graft copolymers as well as the stoichiometric ratio between the guest and host molecules. The properties of the hydrogel were characterized by DSC, X-ray diffraction, and C-13 CP/MAS NMR. The X-ray diffraction data indicated that the gel contains a channel-type crystalline structure, demonstrated by a strong reflection at 2 theta = 20 degrees (d = 4.44 Angstrom). It was confirmed from the DSC and C-13 CP/MAS NMR measurements that all the PEG grafts participate in the complexation. A phase-separated structure consisting of hydrophobic and channel-type crystalline PEG inclusion complex domains and hydrated dextran matrices was suggested as the internal structure, which comprises the supramolecular-structured hydrogel. English American Chemical Society Supramolecular-structured hydrogels showing a reversible phase transition by inclusion complexation between poly(ethylene glycol) grafted dextran and alpha-cyclodextrin Article 10.1021/ma0106649 1 Macromolecules, v.34, no.25, pp.8657 - 8662 Macromolecules 34 25 8657 8662 N scopus 000172414100014 2-s2.0-0035808059 Polymer Science Polymer Science Article MOLECULAR-WEIGHT BIODEGRADABLE POLYROTAXANES DRUG-RELEASE BEHAVIOR DISSOCIATION DEGRADATION