Kim, YS Kim, KM Song, R Jun, MJ Sohn, YS 2024-01-21T11:34:25Z 2024-01-21T11:34:25Z 2021-09-04 2001-12 0162-0134 https://pubs.kist.re.kr/handle/201004/140007 A new series of quinolone-platinum(II) conjugates, [Pt(Q'-NH2)(dmso)X-2] and cis-[Pt(Q"-en)X-2], where Q' and Q" are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X-2 is Cl-2 or 1,1-cyclobutanedicarboxy late, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (H-1 and Pt-195) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line. (C) 2001 Elsevier Science B.V. All rights reserved. English ELSEVIER SCIENCE INC PLATINUM COMPLEXES ANTHRAQUINONE INTERCALATORS CRYSTAL-STRUCTURE DNA GYRASE SERIES LIGANDS AGENTS CYTOTOXICITY INHIBITION MECHANISM Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates Article 10.1016/S0162-0134(01)00345-2 1 JOURNAL OF INORGANIC BIOCHEMISTRY, v.87, no.3, pp.157 - 163 JOURNAL OF INORGANIC BIOCHEMISTRY 87 3 157 163 scie scopus 000172909800005 2-s2.0-0035197497 Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear Biochemistry & Molecular Biology Chemistry Article PLATINUM COMPLEXES ANTHRAQUINONE INTERCALATORS CRYSTAL-STRUCTURE DNA GYRASE SERIES LIGANDS AGENTS CYTOTOXICITY INHIBITION MECHANISM quinolone platinum antitumor agents