Kim, JY Kim, SJ Paeng, KJ Chung, BC 2024-01-21T11:43:07Z 2024-01-21T11:43:07Z 2021-09-05 2001-10 0140-7783 https://pubs.kist.re.kr/handle/201004/140161 A gas chromatographic-mass spectrometric (GC-MS) method for the determination of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), in horse urine by selected ion monitoring (SIM) mode is described. Urine samples (2 mL) were extracted by liquid-liquid extraction with diethyl ether. The residues were then evaporated, derivatized and injected into the GC-MS system. Validation of the GC-MS method in the SIM mode using flurbiprofen as the internal standard (IS) included linearity studies (10-10 000 ng/mL), recovery (95%) and limit of quantitation (LOQ) (10 ng/mL). The response was linear, with a correlation coefficient (0.9998) for ketoprofen. When applied to horse urine samples, the present method allowed detection of ketoprofen up to 16 days in FULL SCAN mode after a topical application of 1.1 g of ketoprofen in a gel formulation. English BLACKWELL SCIENCE LTD PHARMACOKINETICS IDENTIFICATION METABOLITE CAMELS PLASMA DRUGS Measurement of ketoprofen in horse urine using gas chromatography-mass spectrometry Article 10.1046/j.1365-2885.2001.00353.x 1 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, v.24, no.5, pp.315 - 319 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 24 5 315 319 scie scopus 000172046200003 2-s2.0-0034776677 Pharmacology & Pharmacy Veterinary Sciences Pharmacology & Pharmacy Veterinary Sciences Article PHARMACOKINETICS IDENTIFICATION METABOLITE CAMELS PLASMA DRUGS ketoprofen horse urine GC/MS