Kim, SM Kim, DH 2024-01-21T11:43:21Z 2024-01-21T11:43:21Z 2021-09-05 2001-10 0951-4198 https://pubs.kist.re.kr/handle/201004/140165 A sensitive and rapid liquid chromatography/electrospray ion trap mass spectrometry (LC/MS/MS) method has been developed for the quantitative determination of medroxyprogesterone acetate (MPA) in human plasma. Plasma samples (1.0 mL) were simply extracted with pentane and the extracts were analyzed by HPLC with the detection of the analyte in the selective reaction monitoring (SRM) mode. The determination of MPA was accurate and reproducible, with a limit of quantitation of 0.05 ng/mL in plasma. The standard calibration curve for MPA was linear (r = 0.998) over the concentration range 0.05-6.0 ng/mL in human plasma. Analysis precision over the concentration range of MPA was lower than 18.8% (relative standard deviation, RSD) and accuracy was between 96.2 and 108.7%. Copyright (C) 2001 John Wiley & Sons, Ltd. English JOHN WILEY & SONS LTD HUMAN-SERUM Quantitative determination of medroxyprogesterone acetate in plasma by liquid chromatography/electrospray ion trap mass spectrometry Article 1 RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v.15, no.21, pp.2041 - 2045 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 15 21 2041 2045 scie scopus 000171849900010 2-s2.0-0034753793 Biochemical Research Methods Chemistry, Analytical Spectroscopy Biochemistry & Molecular Biology Chemistry Spectroscopy Article HUMAN-SERUM mass spectrum