Shin, KJ Koo, KD Yoo, KH Kang, YK Park, SW Kim, DJ 2024-01-21T11:44:16Z 2024-01-21T11:44:16Z 2021-09-05 2001-09-03 0960-894X https://pubs.kist.re.kr/handle/201004/140181 The synthesis and biological activities of a series of new 1 beta -methylcarbapenems 1a-h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem. (C) 2001 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD ANTIBACTERIAL ACTIVITY Synthesis and biological properties of new 1 beta-methylcarbapenems containing heteroaromatic thioether moiety Article 10.1016/S0960-894X(01)00451-6 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.11, no.17, pp.2397 - 2399 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 11 17 2397 2399 scie scopus 000170627600038 2-s2.0-0035801804 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article ANTIBACTERIAL ACTIVITY 1 β -methylcarbapenems