Kim, SS Jun, K Jeong, MJ Ryu, SH Suh, PG Shin, HS 2024-01-21T12:01:43Z 2024-01-21T12:01:43Z 2021-09-01 2001-09 1226-3613 https://pubs.kist.re.kr/handle/201004/140232 The possible involvement of phospholipase C (PI-C) in the regulation of insulin secretion is not clearly understood and neither its isozymes expressed nor cellular localization in the pancreatic islets is known. By using specific monoclonal antibodies, we have, investigated the expression and localization of eight different PLC isozymes, beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, and gamma2, in the pancreatic islets of adult mice.. immunohistochemical analysis carried out on paraffin embedded sections showed a distinct pattern of expression for each of the PLO isozymes. In the central part of the islets containing P cells, a high level of beta4 and moderate levels of beta3 and gamma1 were expressed, whereas PLC-beta1 and -gamma1 were abundantly expressed in the exocrine pancreas. These results demonstrated the heterogeneity in expression of the phospholipase C isozymes in pancreatic islets. It is conceivable that these isozymes are coupled to different receptors and perform selective tasks in the regulation of insulin secretion for glucose homeostasis. English 생화학분자생물학회 Immunohistochemical localization of eight phospholipase C isozymes in pancreatic islets of the mouse Article 10.1038/emm.2001.28 1 Experimental and Molecular Medicine, v.33, no.3, pp.164 - 168 Experimental and Molecular Medicine 33 3 164 168 Y scopus kci 000171505900009 Biochemistry & Molecular Biology Medicine, Research & Experimental Biochemistry & Molecular Biology Research & Experimental Medicine Article SENSITIVE K+ CHANNELS INSULIN-SECRETION ACINAR-CELLS BETA-CELLS B-CELLS GLUCOSE RELEASE BRAIN ACTIVATION C-GAMMA-1 pancreatic islet beta cell insulin isozymes phospholipase C