Lee, SY Choe, YS Kim, DH Park, BN Kim, SE Choi, Y Lee, KH Lee, JW Kim, BT 2024-01-21T12:32:20Z 2024-01-21T12:32:20Z 2021-09-04 2001-05 0969-8051 https://pubs.kist.re.kr/handle/201004/140515 In vitro metabolism of acetylcholinesterase inhibitors containing 3-[F-18]fluoromethylbenzyl-([F-18]1) and 4-[F-18]fluorobenzyl-piperidine moieties ([F-18]2) was studied and compared with the in vivo metabolism. Defluorination of the [F-18]1 mainly occurred to generate [F-18]fluoride ion both in vitro and in vivo, In contrast, the [F-18]2 was converted into an unknown polar metabolite in both metabolism methods and another metabolite, 4-[F-18]fluorobenzoic acid in vitro. These results demonstrated that the in vitro method can be used to predict the in vivo metabolism of both radiotracers. (C) 2001 Elsevier Science Inc. All rights reserved. English ELSEVIER SCIENCE INC F-18 A simple and efficient in vitro method for metabolism studies of radiotracers Article 10.1016/S0969-8051(01)00203-7 1 NUCLEAR MEDICINE AND BIOLOGY, v.28, no.4, pp.391 - 395 NUCLEAR MEDICINE AND BIOLOGY 28 4 391 395 scie scopus 000169206200005 2-s2.0-0035018171 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging Article F-18 metabolism in vitro method microsome in vivo method radiotracers