Jeong, JM Hong, SH Kim, YJ Lee, DS Chung, JK Cho, JH Lee, MC 2024-01-21T12:37:24Z 2024-01-21T12:37:24Z 2021-09-05 2001-03-30 0362-4803 https://pubs.kist.re.kr/handle/201004/140605 We synthesized N,N ' ,N " ,N ' ' ' -tetraalkylcyclam derivatives in which alkyl groups were ethyl, propyl, butyl, methoxyethyl, and ethoxyethyl. We attempted to label the compounds with Tc-99m. The cyclams with methyl, ethyl, and propyl could be labelled. The labelled N,N ' ,N " ,N ' ' ' -tetraalkylcyclam derivatives showed +1 charge. They excreted rapidly through the kidney in mice. The liver-uptake increased slightly as the lipophilicity increased. However, the myocardial uptake was low unlikely with the +1 charged myocardial imaging agents. English JOHN WILEY & SONS LTD COMPLEX CYCLAM N,N ',N '',N '''-tetraalkylcyclam derivatives: Synthesis, Tc-99m-labelling, and biological properties Article 1 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, v.44, no.4, pp.277 - 285 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 44 4 277 285 scie scopus 000167620400004 2-s2.0-0035970778 Biochemical Research Methods Chemistry, Medicinal Chemistry, Analytical Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article COMPLEX CYCLAM cyclam Tc-99m tetraalkylcyclam tetraazacyclotetradecane