Nam, G Yoon, CM Kim, E Rhee, CK Kim, JH Shin, JH Kim, SH 2024-01-21T12:38:03Z 2024-01-21T12:38:03Z 2021-09-05 2001-03-12 0960-894X https://pubs.kist.re.kr/handle/201004/140617 The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 51 and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA). (C) 2001 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD POTENT PHOSPHODIESTERASE-4 Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors Article 10.1016/S0960-894X(00)00681-8 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.11, no.5, pp.611 - 614 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 11 5 611 614 scie scopus 000167375700001 2-s2.0-0035848414 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article POTENT PHOSPHODIESTERASE-4 PDE 4 inhibitors