Hahn, HG Chang, KH Nam, KD 2024-01-21T12:43:02Z 2024-01-21T12:43:02Z 2021-09-04 2001-02-20 0253-2964 https://pubs.kist.re.kr/handle/201004/140704 A new methodology for construction of dihydro-1,4-dioxin skeleton was described. Introduction of thio group at the alpha -position of 8 followed by chlorination gave 11, which was to prevent an enolization as well as to promote the facile nucleophilic substitution reaction of ethylene glycol giving 16 in equilibrium with cyclic ether 19. Removal of thio group of 19 and dehydration in the presence of an acid catalyst gave dihydro-1,4-dioxin 21. In case of electron withdrawing trifluoromethyl group is subsituted in C-2, 18 was converted to the corresponding dihydro-1,4-dioxin 20 by the halogenation of hydroxy followed by treatment of triethylamine. English KOREAN CHEMICAL SOC Construction of dihydro-1,4-dioxins: Synthesis of dihydro-1,4-dioxin-3-carboxanilides Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.22, no.2, pp.149 - 153 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 22 2 149 153 scie scopus kci other 000167376400008 2-s2.0-0035916164 Chemistry, Multidisciplinary Chemistry Article agrochemical fungicide pesticide dihydro-1,4-dioxin alpha,beta-unsaturated carboxanilide