Kim, DJ Seo, KJ Lee, KS Shin, KJ Yoo, KH Kim, DC Park, SW 2024-01-21T13:05:00Z 2024-01-21T13:05:00Z 2022-01-10 2000-12-18 0960-894X https://pubs.kist.re.kr/handle/201004/140837 A new series of 1 beta -methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability. (C) 2000 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CARBAPENEM Synthesis and biological activity of 1 beta-methyl-2-[5 '-isoxazoloethenylpyrrolidin-3 '-ylthio]carbapenems Article 10.1016/S0960-894X(00)00575-8 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.24, pp.2799 - 2802 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 24 2799 2802 scie scopus 000165849700026 2-s2.0-0034684783 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CARBAPENEM 1 β -methylcarbapenems lsoxazoloethenylpyrrolidine moiety synthesis biological activity