Lee, JH Wee, WR Chung, ES Kim, HY Park, SH Kim, YH 2024-01-21T13:08:48Z 2024-01-21T13:08:48Z 2021-09-05 2000-12 0003-9950 https://pubs.kist.re.kr/handle/201004/140901 Objective: To develop a newly designed double-fixed keratoprosthesis (Seoul-type keratoprosthesis [S-KPro]) and to assess its mechanical stability and biocompatibility. Methods: Twenty-five rabbits were divided into 4 groups by fixation technique, amniotic membrane (AM) implantation, and skirt material. The eyes were studied with the use of slitlamp, light, and electron microscopy. Stress testing was performed. In addition, 2 human subjects underwent S-KPro implantation. Best-corrected visual acuity was checked, and ophthalmic examination was performed. Results: The average retention period of the group receiving double-fixated polyurethante-S-KPro with AM was longer (>24 weeks) than that of the others. Fibroblast invasions were found in polyurethane pores but not in polytetrafluoroethylene (Gore-Tex) pores on light microscopy. The minimal pressure that induced aqueous leakage was greater than 250 mm Hg in all of the tested eyes. Two human subjects have maintained a good postoperative condition for 18 and 8 months. Conclusions: The double-fixation technique of applied S-KPro and AM appears to be helpful in improving the stability of the keratoprosthesis. Polyurethane with relatively large pore size (40 mum) may be used successfully as a material for the keratoprosthesis skirt. Clinical Relevance: Our results may be important for improving the clinical outcome of keratoprosthesis. English AMER MEDICAL ASSOC RABBIT CORNEA FLUOROCARBON SURFACE Development of a newly designed double-fixed seoul-type keratoprosthesis Article 10.1001/archopht.118.12.1673 1 ARCHIVES OF OPHTHALMOLOGY, v.118, no.12, pp.1673 - 1678 ARCHIVES OF OPHTHALMOLOGY 118 12 1673 1678 scie scopus 000165738800009 2-s2.0-0033662551 Ophthalmology Ophthalmology Article; Proceedings Paper RABBIT CORNEA FLUOROCARBON SURFACE Keratoprothesis PMMA-PEG graft polymer