Lee, KY Kim, JH Kwon, IC Jeong, SY 2024-01-21T13:09:05Z 2024-01-21T13:09:05Z 2021-09-05 2000-12 0303-402X https://pubs.kist.re.kr/handle/201004/140906 A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregated suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2). English SPRINGER-VERLAG BLOCK-COPOLYMER MICELLES HYDROGEL NANOPARTICLE PHYSICAL ENTRAPMENT DELIVERY DRUG STABILIZATION COMPLEXATION DERIVATIVES BLOOD Self-aggregates of deoxycholic acid modified chitosan as a novel carrier of adriamycin Article 10.1007/s003960000389 1 COLLOID AND POLYMER SCIENCE, v.278, no.12, pp.1216 - 1219 COLLOID AND POLYMER SCIENCE 278 12 1216 1219 scie scopus 000166036800012 2-s2.0-0033638749 Chemistry, Physical Polymer Science Chemistry Polymer Science Article BLOCK-COPOLYMER MICELLES HYDROGEL NANOPARTICLE PHYSICAL ENTRAPMENT DELIVERY DRUG STABILIZATION COMPLEXATION DERIVATIVES BLOOD chitosan deoxycholic acid self-aggregate nanoparticle adriamycin