Myung, SW Chang, YJ Min, HK Kim, DH Kim, M Kang, T Yoo, EA Sohn, YT Yim, YH 2024-01-21T13:14:16Z 2024-01-21T13:14:16Z 2021-09-04 2000-11 0951-4198 https://pubs.kist.re.kr/handle/201004/140999 Using the high performance liquid chromatography/atmospheric pressure chemical Ionization tandem mass spectrometry (NPLC/APCI-MS/MS) technique, together with established trends from the literature, the structures of metabolites and impurities of amiodarone, an anti-arhythmic drug, have been assigned. By comparing analyses of products of incubation with rat liver microsomes with controls in which glucose 6-phosphate dehydrogenase was omitted, metabolites could be distinguished from impurities. Structures for the two proposed metabolites and four impurities are proposed. Copyright (C) 2000 John Wiley & Sons, Ltd. English JOHN WILEY & SONS LTD CHROMATOGRAPHIC ASSAY Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry Article 1 RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v.14, no.21, pp.2046 - 2054 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 14 21 2046 2054 scie scopus 000090102700014 2-s2.0-0033791105 Biochemical Research Methods Chemistry, Analytical Spectroscopy Biochemistry & Molecular Biology Chemistry Spectroscopy Article CHROMATOGRAPHIC ASSAY amiodarone metabolite APCI MS