Song, R Kim, KM Sohn, YS 2024-01-21T13:14:33Z 2024-01-21T13:14:33Z 2022-01-10 2000-10-20 0253-2964 https://pubs.kist.re.kr/handle/201004/141004 Acylation of an intermediate tetrahydroxoplatinum(IV) complex, [Pt(OH))(4)(dach)] (dach = trans-(+/-)-1,2-diaminocyclohexanl), with one or two kinds of carboxylic anhydrides in stepwise manner afforded various carboxylatoplatinum(IV) complexes, [Pt(O2CR)(x)(OR')(4-x)(dach)] (R = (CH2)(3)CH3 or C(CH3)(3), R' = H or OCCH3, and x = 1-4) with a wide range of lipophilicity. The title complexes were subjected to bioassay using the murine leukemia L1210 cell line, and in particular, their in vivo oral antitumor activity was attempted to correlate with their lipophilicity and water solubility. The most orally active complex exhibited intermediate lipophilicity and water solubility, but it has been found that an exact relationship between the lipophilicity and oral anticancer activity could not be established, since the lipophilicity of the complexes is not the sole parameter to determine the oral activity. One of the important intermediate complexes partially substituted was subjected to X-ray analysis for positional assignment of the substituted group:[Pt(OPiv)(3)(OH)(dach)] crystallizes in the tetragonal system, space group P (4) over bar2(1C) with a = 21.161(3)Angstrom b = 21.161(6) Angstrom, c = 12.816(3) Angstrom, alpha= beta = gamma= 90 degrees, V = 5739(2) Angstrom and Z = 8. English KOREAN CHEMICAL SOC CARCINOMA CELL-LINES PLATINUM COMPLEX CARBOXYLATION CYTOTOXICITY RESISTANT ISOMERS CRYSTAL WATER Lipophilicity vs. antitumor activity of carboxylatoplatinum(IV) complexes Article 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.21, no.10, pp.1000 - 1004 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 21 10 1000 1004 scie scopus 000166386800012 2-s2.0-0034692912 Chemistry, Multidisciplinary Chemistry Article CARCINOMA CELL-LINES PLATINUM COMPLEX CARBOXYLATION CYTOTOXICITY RESISTANT ISOMERS CRYSTAL WATER antitumor agent platinum