Baek, H Cho, Y Lee, CO Sohn, YS 2024-01-21T13:32:05Z 2024-01-21T13:32:05Z 2021-09-05 2000-10 0959-4973 https://pubs.kist.re.kr/handle/201004/141062 A new class of water-soluble cyclotriphosphazene-(diamine)platinum(II) conjugate drugs [NP(Am . Li-2)(Am . PtA(2))](3) (Am: dicarboxylic amino acid; AP: diamine) has been synthesized and characterized by means of elemental analysis, multinuclear (H-1, P-31, C-13, Pt-195) NMR and IR spectroscopies. All the title compounds were subjected to both in vitro and in vivo assays against the murine leukemia L1210 cell line and selected human tumor cells. Most of the title compounds have shown higher in vivo antitumor activity than cisplatin and carboplatin, and, in particular, [NP(L-Glu . Li-2)(L-Glu . Pt(-dach)](3) (Glu=glutamate, dach=trans(+/-)-1,2-diaminocyclohexane) showed extraordinary high activity (ILS>500%) equally against both parent and cisplatin-resistant leukemia L1210 cell lines. Furthermore, this candidate compound (KI 60606) exhibited a wider spectrum of in vitro activity by showing higher cytotoxicity against all the selected human tumor cells than cisplatin and, therefore, was subjected to preclinical studies which are now near completion. [(C) 2000 Lippincott Williams & Wilkins]. English LIPPINCOTT WILLIAMS & WILKINS Synthesis and antitumor activity of cyclotriphosphazene-(diamine)platinum(II) conjugates Article 10.1097/00001813-200010000-00008 1 ANTI-CANCER DRUGS, v.11, no.9, pp.715 - 725 ANTI-CANCER DRUGS 11 9 715 725 N scie scopus 000165667100008 2-s2.0-0033664690 Oncology Pharmacology & Pharmacy Oncology Pharmacology & Pharmacy Article PLATINUM(IV) COMPLEXES PHOSPHAZENES ACID CYCLOPHOSPHAZENES POLY(ORGANOPHOSPHAZENES) DERIVATIVES CHEMISTRY POLYMERS REAGENTS anticancer drug antitumor agent conjugate drug cyclotriphosphazene platinum