Jeong, JH Lim, DW Han, DK Park, TG 2024-01-21T13:32:44Z 2024-01-21T13:32:44Z 2021-09-05 2000-10 0927-7765 https://pubs.kist.re.kr/handle/201004/141074 A series of poly(D,L-lactic-co-glycolic acid) (PLGA)/poly(ethyleneglycol) (PEG) di-block copolymers were synthesized by ring-opening polymerization of D,L-lactide and glycolide with different molecular weights of monomethoxy polyethyleneglycol (mPEG) 750, 2000 and 5000 as an initiator. The bulk properties of these co-polymers were characterized by using H-1 NMR spectroscopy, gel permeation chromatography, differential scanning calorimetry (DSC). Electron spectroscopy for chemical analysis (ESCA) results, in which the blend films with the di-block copolymers showed increasing surface oxygen atomic percentage with increasing PEG chain length, indicate that PEG chain segment in the di-block copolymers is surface oriented and enriched onto the surface of the blend films. The extent of protein adsorption onto the surface of these blend films was studied, using iodine radio-labeled human serum albumin, gamma globulin and human growth hormone. The protein adsorption amount was reduced for the blend films prepared with PLGA/PEG 750 and 2000 di-block copolymers, but increased to a great extent for PLCA/PEG 5000 di-block copolymer. This is due to the increased water uptake capacity of the blend film, which absorbed more protein molecules into a swollen polymer matrix in addition to surface adsorption. (C) 2000 Elsevier Science B.V. All rights reserved. English ELSEVIER SCIENCE BV PLA/PEO/PLA TRIBLOCK COPOLYMERS POLY(ETHYLENE GLYCOL) HYDROLYTIC DEGRADATION DRUG-DELIVERY ACID) POLY(LACTIDE-CO-GLYCOLIDE) NANOSPHERES SURFACES COATINGS Synthesis, characterization and protein adsorption behaviors of PLGA/PEG di-block co-polymer blend films Article 10.1016/S0927-7765(99)00162-9 1 COLLOIDS AND SURFACES B-BIOINTERFACES, v.18, no.3-4, pp.371 - 379 COLLOIDS AND SURFACES B-BIOINTERFACES 18 3-4 371 379 scie scopus 000088810100018 2-s2.0-0033924862 Biophysics Chemistry, Physical Materials Science, Biomaterials Biophysics Chemistry Materials Science Article PLA/PEO/PLA TRIBLOCK COPOLYMERS POLY(ETHYLENE GLYCOL) HYDROLYTIC DEGRADATION DRUG-DELIVERY ACID) POLY(LACTIDE-CO-GLYCOLIDE) NANOSPHERES SURFACES COATINGS di-block copolymer PLGA PEG protein adsorption water uptake