Song, R Kim, KM Lee, SS Sohn, YS 2024-01-21T13:38:22Z 2024-01-21T13:38:22Z 2022-01-10 2000-08-07 0020-1669 https://pubs.kist.re.kr/handle/201004/141169 A novel series of (diamine)platinum(IV) complexes of mixed carboxylates have been synthesized by electrophilic substitution of the tetrahydroxoplatinum(IV) complex (dach)Pt(OH)(4) (dach = trans-(+/-)-1,2-diaminocyclohexane) with three different carboxylic anhydrides, pivalic, acetic, and trifluoroacetic anhydrides. Consecutive two-step acylations with two different carboxylic anhydrides in acetone or dichloromethane gave the mixed carboxylate complexes (dach)Pt(O2CR)(x)(O2CR')(4-x) (R = C(CH3)(3) or CF3, R = CH3, x = 1-4) including all the possible stereoisomers, which could be separated and identified by means of HPLC, column chromatography, H-1 NMR, and X-ray crystallography. From analysis of the reaction products we have found that the positions of electrophilic substitution of (dach)Pt(OH)(4) were influenced by the kinds of carboxylic anhydrides exhibiting different electrophilicity or steric effects. The initial substitution by the first reactant occurs more favorably on axial OH, but in the case of pivalic anhydride, equatorial substitution is favored probably because of the bulkiness of the pivalate group. Such a result seems to be related to their stereochemical factors rather than to differences in electrophilicity. The lipophilicity of the title complexes was affected not only by the carbon numbers of substituents but also by the conformation of the resulting compound. English AMER CHEMICAL SOC PLATINUM(IV) COMPLEXES ANTICANCER DRUG PHASE-I ANTITUMOR REDUCTION DNA Electrophilic substitution of (diamine)tetrahydroxoplatinum(IV) with carboxylic anhydrides. Synthesis and characterization of (diamine)platinum(IV) complexes of mixed carboxylates Article 10.1021/ic9913886 1 INORGANIC CHEMISTRY, v.39, no.16, pp.3567 - 3571 INORGANIC CHEMISTRY 39 16 3567 3571 scie scopus 000088717900021 2-s2.0-0034617582 Chemistry, Inorganic & Nuclear Chemistry Article PLATINUM(IV) COMPLEXES ANTICANCER DRUG PHASE-I ANTITUMOR REDUCTION DNA Platinum Anticancer drug Electrophilic substitution