Choi, S Jung, SY Rhim, H Jeong, SW Lee, SM Nah, SY 2024-01-21T13:41:50Z 2024-01-21T13:41:50Z 2021-09-05 2000-07-14 0024-3205 https://pubs.kist.re.kr/handle/201004/141230 The analgesic effect of ginsenosides or morphine was first determined following intrathecal (i.t.) administration in rat tail-flick test. The effect of chronic i.t. co-administration of ginsenosides with morphine on the development of opioid tolerance were also examined using rat tail-flick test. Administration of ginsenosides (i.t.) produced a weak antinociception in a dose-dependent manner. Administration of morphine (i.t.) also produced antinociception in a dose-dependent manner. The ED(50) was 1.20 mu g (1.14-1.29 mu g). However, acute i.t. co-administration of ginsenosides with morphine was not additive in antinociception. Repeated i.t. co-administration of 200 mu g ginsenosides with 10 mu g morphine inhibited the development of tolerance induced by 10 mu g morphine in rat tail-flick test, although i.t. co-administration of 50 or 100 mu g ginsenosides with morphine was without effect. In conclusion, these results indicate that i.t. administered ginsenosides produce an antinociception in rat tail-Rick test and also prevent opioid tolerance caused by chronic treatment with morphine at the spinal sites. (C) 2000 Elsevier Science Inc. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD PHARMACOLOGICAL ACTIONS GINSENG EXTRACT PANAX-GINSENG MORPHINE ANTINOCICEPTION ANTAGONISM SAPONINS MOUSE MICE Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system Article 10.1016/S0024-3205(00)00682-2 1 LIFE SCIENCES, v.67, no.8, pp.969 - 975 LIFE SCIENCES 67 8 969 975 scie scopus 000088400500012 2-s2.0-0034647590 Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine Pharmacology & Pharmacy Article PHARMACOLOGICAL ACTIONS GINSENG EXTRACT PANAX-GINSENG MORPHINE ANTINOCICEPTION ANTAGONISM SAPONINS MOUSE MICE ginsenosides opioid spinal cord tolerance pain analgesia