Shin, KJ Koo, KD Yoo, KH Kim, DC Kim, DJ Park, SW 2024-01-21T13:42:17Z 2024-01-21T13:42:17Z 2022-01-10 2000-07-03 0960-894X https://pubs.kist.re.kr/handle/201004/141238 The synthesis and biological activities of a series of new 1 beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem. (C) 2000 Elsevier Science Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CARBAPENEMS DERIVATIVES THIENAMYCIN C-2 Synthesis and biological properties of new 1 beta-methylcarbapenems having tetrazolothioether moiety Article 10.1016/S0960-894X(00)00253-5 1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.13, pp.1421 - 1425 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 13 1421 1425 scie scopus 000087776000005 2-s2.0-0034601290 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article CARBAPENEMS DERIVATIVES THIENAMYCIN C-2 1β-methylcarbapenems tetrazolothioether moiety synthesis biological properties