Choo, HYP Peak, KH Park, J Kim, DH Chung, HS 2024-01-21T14:03:38Z 2024-01-21T14:03:38Z 2021-09-05 2000-06 0223-5234 https://pubs.kist.re.kr/handle/201004/141359 The alpha,beta-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly. (C) 2000 Editions scientifiques et medicales Elsevier SAS. English EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER ANGIOTENSIN-CONVERTING ENZYME ANTIHYPERTENSIVE AGENTS CARBOXYPEPTIDASE-A ACIDS Design and synthesis of alpha,beta-unsaturated carbonyl compounds as potential ACE inhibitors Article 10.1016/S0223-5234(00)00158-6 1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.35, no.6, pp.643 - 648 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 35 6 643 648 scie scopus 000088599700008 2-s2.0-0033947207 Chemistry, Medicinal Pharmacology & Pharmacy Article ANGIOTENSIN-CONVERTING ENZYME ANTIHYPERTENSIVE AGENTS CARBOXYPEPTIDASE-A ACIDS alpha,beta-unsaturated amides angiotensin converting enzyme inhibitor irreversible inhibitors